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Wednesday, December 31, 2008

Episode 27 Cardiac Stem Cells

Episode 27 Cardiac Stem Cells
This podcast features an interview by Bronwyn Cleary with Dr Magdelena Kostkiewicz
at the EANM.
The Role of Nuclear Imaging in Evaluating Myocardial Homing of Progenitor Cells and the Impact of Stem Cell Therapy on Myocardial Perfusion and Function.

Background:
In patients after myocardial infarction, stem cell therapy has already shown some clinical promise; however, many fundamental questions remain unanswered. The aim of this study was to evaluate the myocardial viability prior to stem cell transfer and its long-term effect on myocardial perfusion and function. In addition, early myocardial retention of tracer-labeled cells was evaluated.

Material and methods:
46 patients with a large anterior myocardial infarction (peak CK 2399-11213U/L, peak Tn I 68-249 ng/dL) were included in the study 6-9 days after primary PCI. The control group involved 12 patients not subjected to cell therapy (1:4 assignment). To evaluate myocardial perfusion and viability, regional and global left ventricular contractility, GSPECT was performed 2 days prior to autologous CD34+ cells’ transcoronary application. In addition, in a subgroup of 23 consecutive patients the cells were labeled with 99mTc-HMPAO to assess their early myocardial retention (i.e., homing to the infarct zone vs. border zone vs. non-infarcted area, myocardial SPECT) and proportion of retention in the heart vs. other organs (whole body SPECT). After 6 months, GSPECT was repeated.

Results.
In the impaired segments, improvement in both perfusion and ejection (global, regional) fraction was observed at 6 months (45- 49 % in the active group, 52-54% in controls). One hour after transcoronary transfer, 4.72 (1.45-8.42)% activity was detected in the myocardium. In 87% patients there was a clear border-zone engraftment, without any detectable retention in the no-perfusion zone. There was a correlation between peak TnI (but not cell number) and early engraftment efficiency (r=0.54, p=0.052).

Conclusions
; Our preliminary results support the hypothesis that, in patients with a large myocardial infarction, transcoronary implantation of autologous CD34+ cells stem cells has an impact on myocadial perfusion and function at 6 months. However, preferential engraftment of the (viable) border zone indicates that the area of ‘irreversible’ injury (no-perfusion zone) may not be accessible to transcoronary-delivered cells.

Take the Quiz on episode 17 and
Take the Quiz on episode 18
free.

Also I have updated our links and you can get the podcast page at both http://nuccast.com
And http://www.nuccast.com with the feed to put into iTunes or juice or your favorite podcast software can be found at http://molcast.com or http://www.molcast.com. The cardiac subset of the podcast can be found at http://cardiac.nuccast.com and the feed at http://cardiac.molcast.com.


You can get text of the podcasts from
Podzinger


Please pass on information about this podcast to your colleagues and to your CPD provider.
Remember you can get the podcast but going to itunes and entering the search term nuclear medicine best the way to subscribe is via this link


Or you can subscribe by entering your email address below and you will be informed of new episodes

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The easiest way to remember to tell your colleagues about the podcast is via the web link at nuccast.com or molcast.com

Most importantly of all please help this podcast by contributing your opinions, Sound files, emails or phone calls details below:

You click on the little bird icon below and it will allow you to send me a voice mail from your computer.
If you don’t have a microphone then you can
1. Call toll-free anytime 24/7 in the USA at 1-888-65-GCAST (888-654-2278). If outside USA: +1-305-437-8719.
2. Enter the phone number 207-099-2527
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3. Record your message, don’t worry it wont go straight into the podcast unless you ask me too.
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Direct link to itunes 

Direct link to itunes

Sunday, November 30, 2008

Episode 26 Imaging Post Traumatic Stress Disorder



Episode 26 Imaging Post Traumatic Stress Disorder
This podcast features an interview by Bronwyn Cleary with DoctorDr Marcos Pagani
at the EANM.
Neurobiological changes in Post Traumatic Stress Disorder following treatment with Eye
Background:
Only few studies have reported functional or structural modifications in Post-traumatic Stress Disorder (PTSD) patients following pharmacological or cognitive behavioural treatment. Eye movement desensitization and reprocessing (EMDR) is a novel eclectic psychotherapy utilising, among other techniques, relaxation and safe place exercises, cognitive restructuring, future projections, and imaginal exposure of the trauma combined with sensory stimulation. The aim of the study was to analyse the differences in regional cerebral blood flow distribution and in brain volumetry before and after EMDR therapy. Subjects and 

Methods:
Fifteen subjects with chronic PTSD following occupational health hazards were treated with five sessions of EMDR. They were assessed by psychometric scales and diagnostic interviews before and directly after treatment. SPECT during administration of an individualised trauma script, was performed pre- and post-treatment using 99mTc-HMPAO. After EMDR, the subjects were subdivided into responders (R, n=10) and non-responders (NS, n=5), based on the absence or presence, respectively, of full PTSD diagnosis as assessed by DSM-IV criteria. SPECT and volumetric data (MRI, pre-treatment) analyses were carried out by Statistical Parametric Mapping (SPM2) and data were covaried by age and by time elapsed from trauma to SPECT. SPECT data were further covaried by the amount of grey matter normalised by the total intracranial volume. 

Results:
Immediate significant post-treatment changes towards normality in all scales measuring psychological status were found in responders. As compared to NR, R showed a significantly post-treatment decreased tracer uptake in parieto-occipital (Brodmann Area, BA, 37, fusiform gyrus) and in primary visual cortex (BA17) and in the hippocampus (p<0.001). The opposite comparison highlighted an increased tracer uptake in left frontal cortex (BA 44; p<0.05). Volumetric grey matter pre-treatment differences between groups were found in visual, posterior cingulate and parieto-temporal cortex (p<0.05). 
 Conclusion:
The positive EMDR outcome corresponded to increased 99mTc-HMPAO uptake in the left dorsolateral frontal cortex, processing attention and self confidence and exerting an inhibitory effect on the amygdala whose firing is supposed to be responsible for PTSD. After successful treatment significant tracer uptake decreases were found in primary visual cortex, processing images of traumatic memories and flashbacks; in fusiform gyrus, processing the memories of faces, bodies and words and in the hippocampi, involved in episodic and autobiographical memories. Volumetric changes pre-treatment superimposed the neurobiological ones in all previous regions. These findings suggest that the positive clinical effect following EMDR therapy causes functional changes and that volumetric modifications pre-treatment are good predictors of psychotherapy outcome. for those that want to try a quiz for our recent podcast they can go direct to Take the Quiz on episode 17 and
Take the Quiz on episode 18
free.

Also I have updated our links and you can get the podcast page at both http://nuccast.com
And http://www.nuccast.com with the feed to put into iTunes or juice or your favorite podcast software can be found at http://molcast.com or http://www.molcast.com. The cardiac subset of the podcast can be found at http://cardiac.nuccast.com and the feed at http://cardiac.molcast.com.


You can get text of the podcasts from
Podzinger


Please pass on information about this podcast to your colleagues and to your CPD provider.
Remember you can get the podcast but going to itunes and entering the search term nuclear medicine best the way to subscribe is via this link


Or you can subscribe by entering your email address below and you will be informed of new episodes

Enter your email address:

Delivered by FeedBurner



The easiest way to remember to tell your colleagues about the podcast is via the web link at nuccast.com or molcast.com

Most importantly of all please help this podcast by contributing your opinions, Sound files, emails or phone calls details below:

You click on the little bird icon below and it will allow you to send me a voice mail from your computer.
If you don’t have a microphone then you can
1. Call toll-free anytime 24/7 in the USA at 1-888-65-GCAST (888-654-2278). If outside USA: +1-305-437-8719.
2. Enter the phone number 207-099-2527
then enter the PIN 1401
3. Record your message, don’t worry it wont go straight into the podcast unless you ask me too.
Please leave your name and email address in your message so I can get back to you.
You can email me at rob@nuccast.com
Or
nucmedpodcast@gmail.com
Send Me A Message
All contributions welcome, especially as sound files to nucmedpodcast@gmail.com.
Link link to mp3 file

Sunday, October 26, 2008

Episode 25 Sleep Apnea



Episode 25 Sleep Apnea
This podcast features an interview by Bronwyn Cleary with Doctor √únal
at the EANM.



for those that want to try a quiz for our recent podcast they can go direct to Take the Quiz on episode 17 and
Take the Quiz on episode 18
free.

Also I have updated our links and you can get the podcast page at both http://nuccast.com
And http://www.nuccast.com with the feed to put into iTunes or juice or your favorite podcast software can be found at http://molcast.com or http://www.molcast.com. The cardiac subset of the podcast can be found at http://cardiac.nuccast.com and the feed at http://cardiac.molcast.com.


You can get text of the podcasts from
Podzinger


Please pass on information about this podcast to your colleagues and to your CPD provider.
Remember you can get the podcast but going to itunes and entering the search term nuclear medicine best the way to subscribe is via this link


Or you can subscribe by entering your email address below and you will be informed of new episodes

Enter your email address:

Delivered by FeedBurner



The easiest way to remember to tell your colleagues about the podcast is via the web link at nuccast.com or molcast.com

Most importantly of all please help this podcast by contributing your opinions, Sound files, emails or phone calls details below:

You click on the little bird icon below and it will allow you to send me a voice mail from your computer.
If you don’t have a microphone then you can
1. Call toll-free anytime 24/7 in the USA at 1-888-65-GCAST (888-654-2278). If outside USA: +1-305-437-8719.
2. Enter the phone number 207-099-2527
then enter the PIN 1401
3. Record your message, don’t worry it wont go straight into the podcast unless you ask me too.
Please leave your name and email address in your message so I can get back to you.
You can email me at rob@nuccast.com
Or
nucmedpodcast@gmail.com
Send Me A Message
All contributions welcome, especially as sound files to nucmedpodcast@gmail.com.
Link link to mp3 file

Friday, June 06, 2008

Episode 24 Hepatobiliary Nuclear Medicine



Episode 24 Hepatobiliary Nuclear Medicine
This podcast features and interview with Dr Krishnamurthy on hepatobiliary Nuclear Medicine.
The system is available through L&G Medical Software at infor@lgmds.com.

http://www.lgmds.com

for those that want to try a quiz for our recent podcast they can go direct to Take the Quiz on episode 17 and
Take the Quiz on episode 18
without registering but if you are interested in getting CPD point for listening to the podcast please email me at
rob@nuccast.com so I can send you a login code. This is a beta-test program and completely free.

Also I have updated our links and you can get the podcast page at both http://nuccast.com
And http://www.nuccast.com with the feed to put into iTunes or juice or your favorite podcast software can be found at http://molcast.com or http://www.molcast.com. The cardiac subset of the podcast can be found at http://cardiac.nuccast.com and the feed at http://cardiac.molcast.com.


You can get text of the podcasts from
Podzinger


Please pass on information about this podcast to your colleagues and to your CPD provider.
Remember you can get the podcast but going to itunes and entering the search term nuclear medicine best the way to subscribe is via this link


Or you can subscribe by entering your email address below and you will be informed of new episodes

Enter your email address:

Delivered by FeedBurner



The easiest way to remember to tell your colleagues about the podcast is via the web link at nuccast.com or molcast.com

Most importantly of all please help this podcast by contributing your opinions, Sound files, emails or phone calls details below:

You click on the little bird icon below and it will allow you to send me a voice mail from your computer.
If you don’t have a microphone then you can
1. Call toll-free anytime 24/7 in the USA at 1-888-65-GCAST (888-654-2278). If outside USA: +1-305-437-8719.
2. Enter the phone number 207-099-2527
then enter the PIN 1401
3. Record your message, don’t worry it wont go straight into the podcast unless you ask me too.
Please leave your name and email address in your message so I can get back to you.
You can email me at rob@nuccast.com
Or
nucmedpodcast@gmail.com
Send Me A Message
All contributions welcome, especially as sound files to nucmedpodcast@gmail.com.
Link link to mp3 file

Saturday, April 12, 2008

Episode 23 VQ Reprise



Episode 23 VQ Reprise
This podcast features and interview with Dr Bacj from Lund in Sweden on V/Q SPECT.

for those that want to try a quiz for our recent podcast they can go direct to Take the Quiz on episode 17 and
Take the Quiz on episode 18
without registering but if you are interested in getting CPD point for listening to the podcast please email me at
rob@nuccast.com so I can send you a login code. This is a beta-test program and completely free.

Also I have updated our links and you can get the podcast page at both http://nuccast.com
And http://www.nuccast.com with the feed to put into iTunes or juice or your favorite podcast software can be found at http://molcast.com or http://www.molcast.com. The cardiac subset of the podcast can be found at http://cardiac.nuccast.com and the feed at http://cardiac.molcast.com.


You can get text of the podcasts from
Podzinger


Please pass on information about this podcast to your colleagues and to your CPD provider.
Remember you can get the podcast but going to itunes and entering the search term nuclear medicine best the way to subscribe is via this link


Or you can subscribe by entering your email address below and you will be informed of new episodes

Enter your email address:

Delivered by FeedBurner



The easiest way to remember to tell your colleagues about the podcast is via the web link at nuccast.com or molcast.com

Most importantly of all please help this podcast by contributing your opinions, Sound files, emails or phone calls details below:

You click on the little bird icon below and it will allow you to send me a voice mail from your computer.
If you don’t have a microphone then you can
1. Call toll-free anytime 24/7 in the USA at 1-888-65-GCAST (888-654-2278). If outside USA: +1-305-437-8719.
2. Enter the phone number 207-099-2527
then enter the PIN 1401
3. Record your message, don’t worry it wont go straight into the podcast unless you ask me too.
Please leave your name and email address in your message so I can get back to you.
You can email me at rob@nuccast.com
Or
nucmedpodcast@gmail.com
Send Me A Message
All contributions welcome, especially as sound files to nucmedpodcast@gmail.com.
Link link to mp3 file

Saturday, February 09, 2008

Episode 22 D-SPECT




This podcast features and interview with Prof Ben-Haim from UCL in LONDON.

Looking at the revolutionary D-SPECT camera

Pictures of the camera are here D-SPECT camera
for those that want to try a quiz for our recent podcast they can go direct to Take the Quiz on episode 17 and
Take the Quiz on episode 18
without registering but if you are interested in getting CPD point for listening to the podcast please email me at
rob@nuccast.com so I can send you a login code. This is a beta-test program and completely free.

Also I have updated our links and you can get the podcast page at both http://nuccast.com
And http://www.nuccast.com with the feed to put into iTunes or juice or your favorite podcast software can be found at http://molcast.com or http://www.molcast.com. The cardiac subset of the podcast can be found at http://cardiac.nuccast.com and the feed at http://cardiac.molcast.com.


You can get text of the podcasts from
Podzinger


Please pass on information about this podcast to your colleagues and to your CPD provider.
Remember you can get the podcast but going to itunes and entering the search term nuclear medicine best the way to subscribe is via this link


Or you can subscribe by entering your email address below and you will be informed of new episodes

Enter your email address:

Delivered by FeedBurner



The easiest way to remember to tell your colleagues about the podcast is via the web link at nuccast.com or molcast.com

Most importantly of all please help this podcast by contributing your opinions, Sound files, emails or phone calls details below:

You click on the little bird icon below and it will allow you to send me a voice mail from your computer.
If you don’t have a microphone then you can
1. Call toll-free anytime 24/7 in the USA at 1-888-65-GCAST (888-654-2278). If outside USA: +1-305-437-8719.
2. Enter the phone number 207-099-2527
then enter the PIN 1401
3. Record your message, don’t worry it wont go straight into the podcast unless you ask me too.
Please leave your name and email address in your message so I can get back to you.
You can email me at rob@nuccast.com
Or
nucmedpodcast@gmail.com
Send Me A Message
All contributions welcome, especially as sound files to nucmedpodcast@gmail.com.
Link link to mp3 file